ZFIN Image: Ahlberg et al., 2018, Fig. S11

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Figure Caption

Fig. S11

Defective z-discs in a zebrafish titin truncated homozygous mutant

Top panel) Isolated hearts form 72 hours post fertilization old zebrafish stained for alpha-actinin, an important component of the Z-disc, revealed well-defined z-discs in both the atria (right chamber) and ventricle (left chamber) in the WT siblings. A close up of the atria (right) show well-defined z-discs (red arrows). Bottom panel) Compared to the observations made in the isolated hearts from the WT sibling embryos, the homozogous mutant embryos showed a no well-defined z-discs, and an aberrant alpha-actinin expression in the atria (indicated by the red arrows in the bottom right image) and the ventricle indicating a compromised sarcomere architecture. Scale bars = 20μm. Please see supplementary Figure 9-10 for complete z-stacks.

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Acknowledgments

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