ZFIN Image: Sarangdhar et al., 2018, Fig. 5

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Figure Caption

Fig. 5

Ectopic over-expression of miR-7 leads to defective ventricle opening and it is rescued by Cyrano. First panel shows control mimic injected zebrafish embryos, second panel with 300 pg of miR-7 mimic injected embryos, third panel has embryos injected with 6 pg of Cyrano transcript and 300 pg of miR-7 mimic and fourth panel has embryos injected with 6 pg of miR-7 resistant Cyrano transcript (miR-7 res Cyrano) along with 300 pg of miR-7 mimic imaged at 24 hpf. Defects were observed (shown by dotted arrow) in 70 out of 124 animals with miR-7 mimic injection and these defects were restricted to 5 out of 23 and 13 out of 48 animals after rescue with wild type Cyrano or miR-7 res Cyrano, respectively. Forebrain (F), Midbrain (M), Hindbrain (H) ventricles shown by dotted lines.

Acknowledgments

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