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Fig. S10
GSK3 inhibition rescues LY294002-induced tail regeneration defects.
(A) Representative micrographs of 5-dpf larval tails that were amputated at 2 dpf and treated with 0.5% DMSO, 10 μM LY294002, or 10 μM LY294002 + 100 nM BIO for the next 24 hours. Scale bar: 100 μm. (B) Caudal fin sizes at 5 dpf (3 dpa) for the indicated amputation and inhibitor treatment regimens (compound administration from 2 to 3 dpf). Data are the average caudal fin areas of 15 larvae ± s.e.m., normalized to the average fin size of uncut larvae treated with 0.5% DMSO. ***, P < 0.001.
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