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Fig. S3
Inhibition of larval tail regeneration by pathway-specific antagonists.
Representative micrographs of larval tails that were amputated at 2 dpf and then treated with the following signaling pathway inhibitors for 3 days: (A) 0.5% DMSO; (B) 75 μM PD173074 (FGF); (C) 10 μM LY294002 (PI3K); (D) 50 μM SB431542 (TGFß); (E) 5 μM SP600125 (JNK); (F) 50 μM DAPT (Notch); (G) 100 μM cyclopamine (Hh); or (H) 50 μM dorsomorphin (BMP). At least 30 larvae were analyzed for each experimental condition, and phenotypic descriptions were based on a penetrance of > 80%. Scale bar: 100 μm.
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