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Fig. 4
Multiple signaling pathways regulate the onset and maintenance of has3 expression during larval tail regeneration.
Expression of has3 in 1-dpa (3-dpf) larval tails treated with the following signaling pathway inhibitors for the first 24 hours after amputation: (A, A’) 0.5% DMSO. (B, B’) 75 μM PD173074 (FGF). (C, C’) 10 μM LY294002 (PI3K). (D, D’) 50 μM SB431542 (TGFß). (E, E’) 5 μM SP600125 (JNK). (F, F’) 50 μM DAPT (Notch). At least 30 larvae were analyzed for each experimental condition, and phenotypic descriptions were based on a penetrance of > 80%. Scale bar: 100 μm.
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