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Fig. S3
Two-color analysis of rhombomere identity with cyp26c1.
The expression of cyp26c1 is examined in combination with krox20. Cyp26c1 is shown in purple, while krox20 is shown in red. Krox20 expression labels r3 and r5. Cyp26c1 expression is observed in r2/4/6 in wildtype (A) and hoxb1a−/− mutants (B). The loss of hoxb1b causes a downregulation of cyp26c1 in r4 (C,D). All embryos have been genotyped for hoxb1asa1191 and hoxb1bua1006. All images are dorsal views, anterior to the left, 4–5 somites.
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Reprinted from Mechanisms of Development, 150, Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J., Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development, 28-41, Copyright (2018) with permission from Elsevier. Full text @ Mech. Dev.