ZFIN Image: Gou et al., 2018, Fig. 6

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Figure Caption

Fig. 6

Interaction betweenpax8-/-andpax2a-/-during otic development. (A-C) Expression of pax2a at 12 hpf in control (A), pax2a-/- (B) and pax2a-/-; pax8-/- (C) embryos (dorsal views, anterior to the top). Staging of embryos was confirmed by myoD expression in somites. (D-F) Lateral views (anterior to left) of the otic vesicle in control (D), pax2a-/- (E) and pax2a-/-; pax8-/- (F) embryos imaged live at 26 hpf. The small otic vesicle in the pax2a-/-; pax8-/- double mutant (F) is marked with an arrow. (G-L) Dorsal views (anterior to left) showing expression of cldna (G-I) and pax2a (J-L) at 25 hpf and 23 hpf respectively in control (G, J), pax2a-/- (H, K) and pax2a-/-; pax8-/- (I, L) embryos. Arrows indicate otic expression domains. Scale bars (D-L), 50 µm.

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Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Guo, J., Maulding, K., Riley, B.B., sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish, 84-95, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.