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Fig. S2
Sonic Hedgehog ligand (Shha) is required for habenular development.
Whole-mount in situ hybridization against cxcr4b at 36 hpf (A,A’,B,B’) or brn3a at 48 hpf (C,C’,D,D’) showing heads (A-D) or the epithalamus (A’-D’) of wild type (A,A’,C,C’) or shhatbx392 embryos (B,B’,D,D’). While the expression of cxcr4b and brn3a is detected in the habenulae of all the wild type siblings (n = 8 and n = 14 respectively), the expression of both genes is strongly reduced in the epithalamus of shhatbx392 mutant embryos (B,B’, n = 12/13 and D,D’, n = 6/6). Embryos are viewed dorsally with anterior up.
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