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Fig. 5
Interferon target genes are induced in the head, jaw and liver in uhrf1 mutants. ISH for irf1b and isg15, two of the most upregulated interferon genes, in 80 and 120 hpf uhrf1 and WT siblings (3-6 embryos per group/per time point). Staining is particularly intense along the caudomedial edge of the optic tectum (white arrowhead), ear (asterisk) and liver (black arrowhead) at 120 hpf for both genes. n=15, clutches=3.
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