Gene

irf1b

ID

ZDB-GENE-041114-13

Name

interferon regulatory factor 1b

Symbol

irf1b Nomenclature History

Previous Names

irf11 (2)
irf1 (1)
sb:eu922
zgc:103566

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Exhibits transcription regulatory region DNA binding activity. Involved in regulation of defense response to virus and response to virus. Localizes to nucleus. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; and lung non-small cell carcinoma. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and thymus. Orthologous to human IRF1 (interferon regulatory factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu922 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With irf1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lung cancer	Alliance	Nonsmall cell lung cancer, somatic	211980
stomach cancer	Alliance	Gastric cancer, somatic	613659
		Immunodeficiency 117, mycobacteriosis, autosomal recessive	620668

Associated With irf1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019817	Interferon regulatory factor, conserved site
Domain	IPR001346	Interferon regulatory factor, DNA-binding domain
Family	IPR017431	Interferon regulatory factor-1/2
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily