ZFIN Image: Noack Watt et al., 2016, Fig. 6

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Figure Caption

Fig. 6

Increased Tp53-dependent cell death within the neuroepithelium of polr1c^-/- and polr1d^-/- embryos.

(A-C) TUNEL staining (green fluorescence) revealed increased cell death in the cranial region and dorsal tissues of 24 hpf polr1c^-/- and polr1d^-/- mutant embryos. (D-F) Transverse sections revealed that cell death (green fluorescence) occurred primarily within the neuroepithelium. (G) qPCR (H) and Western blot analyses demonstrated the levels of tp53 and Tp53 were increased respectively in 36 hpf and 5 dpf polr1c^-/- and polr1d^-/- mutant embryos compared to controls. α-tubulin was used as a loading control. * = p < 0.05 and error bars represent 95% confidence intervals.

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Acknowledgments

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