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Fig. 7
Amphioxus SoxE promotes differentiation of melanophores and enteric neurons. (A) differentiated melanophores in 96 hpf cls mutants injected with a Tol2:BfSoxE construct. (B-D) anti-HuC/D immunofluoresence in 96 hpf zebrafish indicates the presence of enteric neurons. (B) control wildtype. (C) cls mutants lack HuC/D-positive enteric neurons. (D) BfSoxE promotes differentiation of enteric neurons in cls mutants. Orientation: anterior facing left.
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Reprinted from Developmental Biology, 418(1), Lee, E.M., Yuan, T., Ballim, R.D., Nguyen, K., Kelsh, R.N., Medeiros, D.M., McCauley, D.W., Functional constraints on SoxE proteins in neural crest development: the importance of differential expression for evolution of protein activity, 166-78, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.