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Fig. 4
Melanogenesis in cls mutants resulting from expression of PmSoxE1 and PmSoxE2 sequences inserted into Tol2 vectors. (A-H) 96 hpf zebrafish larvae. Expression of PmSoxE1 (A-D) and PmSoxE2 (E-G) and wildtype melanogenic phenotype (H). (I-V) pigmentation rescue phenotypes categorized as described in the text. Arrows indicate the absence of iridophores in cls mutant larvae (G) versus their presence in wildtype siblings (H).
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Reprinted from Developmental Biology, 418(1), Lee, E.M., Yuan, T., Ballim, R.D., Nguyen, K., Kelsh, R.N., Medeiros, D.M., McCauley, D.W., Functional constraints on SoxE proteins in neural crest development: the importance of differential expression for evolution of protein activity, 166-78, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.