ZFIN Image: de Preux Charles et al., 2016, Fig. 3

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Figure Caption

Fig. 3

Thoracotomy triggers the remodelling of the heart architecture. (a,b) Uninjured and 30 dpt heart sections of transgenic zebrafish cmlc2:DsRed2-nuc (red) after one month of BrdU treatment (green). (c,d) Representative sections of hearts labelled with Phalloidin (red), a muscle marker, at 30 dpt. (e) Representative section of an uninjured heart labelled with haematoxylin/eosin (h,e) staining. Compact myocardium (Comp. MC) is composed of a dense layer of CMs, surrounding the trabecular myocardium (Trab. MC) with a spongy lumen. (a-e) Dashed lines separate compact and trabecular myocardium. (f,g) Percentage of BrdU-positive CMs in whole myocardium (f) or in the two distinct myocardium compartments (g). (h-j) Morphometric measurements of hearts at 30 dpt. No difference in heart size was noticed (h), but a thickening of the compact myocardium was observed (i). (j) The density of CMs (number of CMs per 10 000 µm² of cardiac muscle) is higher at 30 dpt in comparison to uninjured control (n e 4 hearts; e2 sections per heart; *p < 0.05; ***p < 0.001).

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Acknowledgments

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