Image
|
Figure Caption
Fig. 7
Inhibition of IGF signalling impairs CM proliferation. (a-d) Sections of cmlc2::DsRed2-Nuc (red) hearts at 7 dpci reveal that the treatment with 5 µM NVP-ADW742 (inhibitor of Igf1r) significantly reduces p-Igf1r levels (a,b, green) and MCM5-positive CMs (c,d, green). (e-f) Quantification of p-Igf1r (e, N ≥ 4) and the number of proliferating CMs (f, N ≥ 10) in the whole ventricles at 7 dpci. **p < 0.01, ***p < 0.001. Dashed lines encircle the cryoinjured areas. Scale bars, 100 µm.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Open Biol.