ZFIN Image: Dutta et al., 2015, Fig. 2

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Fig. 2

Nlz1 is important for left–right patterning in zebrafish. Zebrafish embryos were injected with control MO (A), (D), and (G) or with 2 ng of Nlz1 MO (B), (B2), (E), (E′), (H), and (H′). Embryos were hybridized in situ with laterality marker genes spw (A), (B), (B′), lft2 (D), (E), and (E2), and cmlc2 (G), (H), (H′) RNA probes. Quantification of expression patterns of spw (C), lft2 (F), and cmlc2 (I) in MO (spw, n=85; lft2, n=110; cmlc2, n=75) and MO+mRNA injected embryos (spw, n=75; lft2,n=100; cmlc2, n=55). (A), (B), (B′), (D), (E), (E′) dorsal view at 18–20S stage, (G), (H), (H′) frontal view at 28 h. Scale bar 100 µm. Ab: absent; Bi: bilateral, M: midline; R: right; L: left.

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Acknowledgments

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Reprinted from Developmental Biology, 406(2), Dutta, S., Sriskanda, S., Boobalan, E., Alur, R.P., Elkahloun, A., Brooks, B.P., nlz1 Is required for cilia formation in zebrafish embryogenesis, 203-11, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.