ZFIN Image: Mastracci et al., 2015, Fig. 8

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Figure Caption

Fig. 8

Pharmacological inhibition of DHS with GC7 phenocopies genetic loss of dhps and inhibition of ODC.

(a) Inhibitor treatment strategy. Representative maximum intensity projection images of the pancreas from (b) control and (c) GC7-treated Tg(ptf1a:gfp) embryos; for comparison single channel images are also provided for ptf1a:GFP expression in (b′) control and (c′) GC7-treated embryos, and insulin expression in (b′′) control and (c′′) GC7-treated embryos. (d) Quantification of exocrine pancreas length in control (n = 12) and GC7-treated (n = 15) Tg(ptf1a:gfp) embryos at 72 hpf (p < 0.0001); this represents a 40% difference in exocrine pancreas length. (e) Quantification of insulin + β cell number in control (n = 9) and GC7-treated (n = 13) Tg(ptf1a:gfp) embryos at 72 hpf (p = 0.0556). *p < 0.05, **p < 0.01, ***p < 0.001.

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Phenotype details

Acknowledgments

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