ZFIN Image: Wang et al., 2015, Fig. 2, S1

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Figure Caption

Fig. 2, S1

Observation of 2o islet formation in live β/δ-reporter larvae after drug treatment.

(A, B) Representative in vivo confocal images - brightfield and fluorescence images merged-of pancreata in β/δ-reporter larvae following treatment with 0.1% DMSO (A) or a representative Hit I drug (B, Beta-estradiol) from 3 to 7 dpf. White arrows indicate 2° islets in the tail of the pancreas. Scale bar = 25 µm. (C) Percentages of larvae having 2° islets following treatment from 3 to 7 dpf with the indicated control of Hit I compounds at optimal concentrations. n > 20. negative control: 0.1% DMSO. Positive control: RO2949097 (5 µM).

Acknowledgments

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