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Fig. S12 pax2a morpholino knockdown recapitulates the phenotypes displayed by noi homozygous mutant embryos, and was not associated with ectopic pronephros expression of podocyte genes in proximal and distal tubule domains. In 28 hpf wild-type embryos, wt1a and wt1b are expressed in the podocyte clusters with wt1a transcripts extending rostrally outside the podocyte domain. Conversely, pax2a morphant embryos have both wt1a and wt1b transcripts in an expanded caudal domain that phenocopies noi mutant embryos.
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Reprinted from Developmental Biology, 396(2), Gerlach, G.F., Wingert, R.A., Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta, 183-200, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.