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Fig. 1 Pharmacological inhibition of Nodal signaling by SB505124 prevents osr1 expression. A–F: Animal pole views. A′–F′: Dorsal views. osr1 expression in the germ ring (A) and shield (A′) is absent in embryos treated with 50 µM SB505124 from 2.5 hpf until the embryo was fixed at shield stage (6 hpf, D, D′). sox17 expression (B, B′) in the endoderm and forerunner cells (B′) is also absent in SB505124-treated embryos (E, E′) demonstrating that a complete block of Nodal signaling is achieved by SB505124. ntl expression (C, C′) requires Nodal signaling only in the most dorsal region (F, F′).
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