IMAGE

Fig. 2

ID
ZDB-IMAGE-150311-2
Source
Figures for Zhao et al., 2014
Image
Figure Caption

Fig. 2

Inhibition of Notch signaling following amputation injury prevents cardiac regeneration. (A–D) Inhibition of Notch signaling impairs cardiac regeneration. Representative cardiac sections from heat shocked control (A and C) and Tg(hsp70:DN-MAML) (B and D) animals 30 dpa evaluated by AFOG staining (A and B) or immunofluorescence (C and D) for the myocardial marker TPM. Whereas heat shocked control animals robustly regenerated myocardium (asterisks in A and C), Tg(hsp70:DN-MAML) hearts failed to regenerate new myocardium (arrowheads in B and D) instead showing evidence of residual fibrin (red in B) and collagen deposition (blue in B). Cardiac regeneration failed in 0 of 24 heat shocked control animals and 34 of 35 heat shocked Tg(hsp70:DN-MAML) animals.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA
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