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Fig. 7
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Fig. 7 MZjek mutants show left–right patterning defects despite having intact embryonic midlines. (A–D) WISH for lefty1,2 (A,C; N=80,116) and spaw (B,D; N=16,43) in wildtype and MZjek embryos at 21 SS. (E) Percentage of embryos displaying left, right, bilateral and absent lefty1,2 and spaw expression in 20–22 SS wildtype (wt) and MZjek mutant embryos. (F–K) Midline markers shh (F,I), ntl (G,J), and lefty1 (H,K) are expressed continuously along the embryonic axis in both wildtype and MZjek embryos, indicating an intact midline.
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Reprinted from Developmental Biology, 387(2), Superina, S., Borovina, A., and Ciruna, B., Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry, 154-166, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.