ZFIN Image: Perathoner et al., 2014, Fig. 3

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Figure Caption

Fig. 3

The alf phenotype is due to gain-of-function mutations within the K⁺ channel kcnk5b.

(A) alf mutations map to chromosome 20 between z11841 and z21067. Gray: north markers; blue: south markers. (B) Electropherogram of kcnk5b at position 169 and 241 in mutants and wild type siblings. (C) The amino acids affected in the mutants are well conserved among vertebrates. (D) A revertant of alf^dty86d (j131x8) shows wild type-sized fins. (E) kcnk5b^j131x8 fish harbor an intragenic deletion in kcnk5b that is predicted to cause a truncated protein lacking three transmembrane (TM) domains.

Figure Data

Phenotype details

Acknowledgments

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