IMAGE

Fig. 2

ID

ZDB-IMAGE-140731-29

Genes

Antibodies

Ab1-ctbp2l

Source

Figures for George et al., 2014

Image

Figure Caption

Fig. 2

Some synaptic proteins are mislocalized in nrc^a14 cone photoreceptors.

Tg(TαCP:spH) WT and nrc^a14 5 dpf retinal slices were stained with an antibody against the ribbon synapse protein RibeyeB (A–F). In WT photoreceptors, RibeyeB was found only at synaptic terminals (A). In nrc^a14 cone photoreceptors, RibeyeB (D, arrowhead) and VAMP2 (E, arrowhead) were detected in both synaptic terminals and ISs. Mislocalized signals for RibeyeB (magenta) and VAMP2 (green) were coincident in the ISs of nrc^a14 cone photoreceptors (F, arrowhead). In contrast, the synaptic vesicle protein Synaptophysin (Syp-CFP) had a primarily synaptic distribution in both WT (G) and nrc^a14 (H) cone photoreceptors. Live confocal images were taken of 5 dpf Tg(TαCP:Syp-CFP) WT and nrc^a14 larvae. Syn = photoreceptor synapses, IS = inner segment. Scale bar = 2 μm.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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