ZFIN Image: Okigawa et al., 2014, Fig. 4

Image

Figure Caption

Fig. 4 Notch1a, Notch1b, and Notch3 together contribute to p2 progenitor maintenance. p2 Progenitors in the ventricular zone detected by irx3a (A) or nkx6.1 (B) were reduced in notch1a/notch1b/notch3 knockdown embryos (90%, irx3a, n=10; 80%, nkx6.1, n=10). Other single or double knockdown embryos did not show a striking reduction in irx3a (A) or nkx6.1 (B) expression compared with the notch1a/notch1b/notch3 knockdown embryos. All panels: side views of embryos at 24 hpf with anterior to the left, dorsal up. Dorsal and ventral borders of the neural tubes are shown by the dotted lines. Bar scale: 100 µm.

Figure Data

Expression / Labeling details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 391(2), Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M., Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination, 196-206, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.