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Fig. 3
Kidney defects in 8 dpf dxavu463 mutant zebrafish.
(A) Toluidine blue staining in pre-TEM sections at 8 dpf. Various sized vacuoles were observed in the dxa mutants. (B) ORO staining showing marked increase in lipids in dxa mutants. (C) TEM of kidney epithelium in wild type (left) and dxa mutants (right). Green colored regions indicate rod-shaped mitochondria in the kidney. (D) Filipin staining again shows free cholesterol accumulation in the cytosol of kidney cells. N, nuclei. Scale bar = 50 μm (A, B, D) and 2 μm (C).
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