ZFIN Image: Glenn et al., 2013, Fig. 6

Image

Figure Caption

Fig. 6

cAMP does not rescue myelination in erbb2 mutants. (A,B) Lateral views of zebrafish embryos at 2 dpf. Anterior is to the left and dorsal to the top in all panels. Schwann cells (marked by sox10, arrow in B) are not present along the PLLn in erbb2^st61/st61 mutants (A, n=15), but migration is rescued upon injection of erbb2 mRNA (B, n=38). (C-F) Lateral views of zebrafish larvae at 5 dpf showing expression of mbp in (C) control erbb2^st61/+ (arrow indicates PLLn), (D) erbb2^st61/st61 mutant, (E) erbb2^st61/st61 mutant with rescued Schwann cell migration, and (F) erbb2^st61/st61 mutant with rescued Schwann cell migration that was also treated with a FSK pulse from 50 to 55 hpf. mbp expression was not observed in the PLLn of erbb2^st61/st61 mutants, even when Schwann cell migration was rescued with erbb2 mRNA injection and cAMP was elevated by FSK treatment. White asterisks mark mbp expression in the CNS. The number of fish analyzed in C-F is: C, n=60; D, n=8; E, n=10; F, n=12. Scale bars: 100 μm.

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Acknowledgments

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