ZFIN Image: Sorrell et al., 2013, Fig. 9

Image

Figure Caption

Fig. 9

Tcf7l1s cell autonomously repress anterior endothelial cell development. ((A)and (B)) Control and Tcf7l1 deficient Tg(kdrl:EGFP) embryos. Tcf7l1 deficient Tg(kdrl:EGFP) embryos have a dramatic loss of the ACEs at 28 hpf. (C) Schematic of the cell transplantation strategy used for assessing cell autonomy. Red indicates injection with the rhodamine-dextran lineage tracer. (D) Representative image of cranial ECs from donor WT/Tg(kdrl:EGFP) cells transplanted into a WT host. View is fronto-lateral. (E) Representative image of cranial ECs from donor Tcf7l1 deficient/Tg(kdrl:EGFP) cells transplanted into a WT host. View is frontal. (F) Frequency of ACEs found in transplantation experiments. Asterisk indicates a statistically significant difference compared to control transplant experiments.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 380(2), Sorrell, M.R., Dohn, T.E., D'Aniello, E., and Waxman, J.S., Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish, 199-210, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.