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Fig. S4
Zebrafish lrrc50Hu255h tumor proliferation and genotyping various stages of tumor progression. (A) Quantification of single stem cell proliferation from phospho-HistoneH3 staining; lrrc50+/ (T; tumors, n = 7), wt (n = 5) and age-matched vhl+/ (n = 4). Statistical analysis was performed using a non-parametric Mann-Whitney test at P<0.05. (B) Analysis of the tumor progression, defined by SPG content determined by α-Ziwi IHC and morphologically identifiable sperm content, correlates with increased biallelic loss indicated by tumor genotypes. Scale bars; 50 μm.
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