ZFIN Image: Sorrells et al., 2012, Fig. S6

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Figure Caption

Fig. S6 p53-mediated puma expression causes neurodegeneration in rs7 mutants. (A) rs7 sibling or mutant embryos in the p53 wild-type or mutant background were collected, and RNA was harvested at 30 hpf, reverse transcribed and analyzed for the expression of puma mRNA by qPCR. Rs7 mutants and siblings were distinguished by morphology since loss of p53 does not inhibit the rs7-mediated “curly-up” tail phenotype. (B) Pictures were taken of 48 hpf embryos from (A). Arrows point to neurodegeneration in rs7 mutants that is substantially rescued by loss of wild-type p53. For panel (A), error bars represent the standard error from three independent experiments.

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Phenotype details

Acknowledgments

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