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Fig. S3 The rs7 mutation causes severe neurodegeneration that culminates in embryonic lethality. Wild-type embryos (derived from wild-type parents) and rs7 mutants were analyzed by brightfield microscopy on day 2 and day 3 of development. The rs7 mutation causes massive accumulation of cell death in the brain and spinal cord likely contributing to a small-head and “curly-up” tail phenotype. Rs7 mutant embryos usually fail to survive past day three.
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