ZFIN Image: van der Velden et al., 2012, Fig. S12

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Figure Caption

Fig. S12 The FGF target genes dusp6, pea3 and spry4 are overexpressed in apc fin mesenchyme. Embryos of the indicated genotypes were stained at 32 hpf (A-L) and 72 hpf (M-X) with the indicated FGF-target genes. dusp6, pea3 and spry4 are expressed in wild-type fin buds at 32 hpf (A,E,I). Expression of all three genes is upregulated in apc fin buds (B,F,J), not detectable in ring1b mutants (C,G,K) and expression is restored, albeit weak, in apc/ring1b mutants (D,H,L). dusp6, pea3 and spry4 are expressed in wild-type growing fins at 72 hpf (M,Q,U). Expression of all three genes is upregulated in the apc fin buds (N,R,V) and not detectable in ring1b fin buds (O,S,W). Expression of the FGF-target genes is restored in the apc/ring1b fin buds (P,T,X).

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