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Fig. 2
Overexpression of ppp4cb mRNA Antagonizes Dorsalizing Effect of ppp4cb Knockdown in Zebrafish Embryos (A) The rescuing effect of ppp4b (p4cb) mRNA on ppp4cb MO1 (bMO1)-induced dorsalized phenotype at the shield stage, as demonstrated by the expression of the dorsal marker gsc and the ventral markers eve1 and gata2. The statistical data are shown in the bar graphs with the number of observed embryos indicated below. (B–G) ppp4cb MO1 (bMO1)-induced dorsalized phenotype (elongated shape) at the bud stage was rescued by coinjection of ppp4cb mRNA, but not ppp4cb-RL (p4cb-RL) mRNA. See also Figure S2.
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Reprinted from Developmental Cell, 22(5), Jia, S., Dai, F., Wu, D., Lin, X., Xing, C., Xue, Y., Wang, Y., Xiao, M., Wu, W., Feng, X.H., and Meng, A., Protein Phosphatase 4 Cooperates with Smads to Promote BMP Signaling in Dorsoventral Patterning of Zebrafish Embryos, 1065-1078, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell