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Fig. S6
Progressive heart phenotype of ftk mutants. (A-L) Morphology of wild-type (A, C, E, G, I, and K) and ftk mutant (B, D, F, H, J, and L) embryos and larvae. The ftk mutant begins to develop heart edema at around 36 hours postfertilization (hpf) (arrow in B), and by 2 days postfertilization (dpf) it shows irregular heart beating and reverse blood flow (arrow in D). At 3 dpf, the area of pericardiac edema enlarges, and the heart chambers become dilated (arrow in F). ftk mutants become bloodless at ~4 dpf (arrow in H). Pericardiac edema expands to the yolk region (arrows in J and L).
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