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Fig. S3
Altered neutrophil homeostasis in Rac2D57N larvae, related to Figure 4.
(A) in 3dpf larvae, compared to Rac2, D57N transgenic larvae have reduced neutrophil number in the head. Arrows point to the pericardium region where most neutrophils are present in D57N larvae.
(B,C,) Quantification of (A). n=58 (Rac2), 46 (D57N) in (B) and n=38 (Rac2), 31 (D57N) in (C). p<0.0001, two-tailed Mann-Whitney test.
(D) Altered neutrophil homeostasis persists at 7dpf. Note, there are fewer neutrophils in kidney in D57N larvae as well. CHT, caudal hematopoietic tissue.
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Reprinted from Developmental Cell, 21(4), Deng, Q., Yoo, S.K., Cavnar, P.J., Green, J.M., and Huttenlocher, A., Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue, 735-745, Copyright (2011) with permission from Elsevier. Full text @ Dev. Cell