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Fig. 6
Rac2D57N Partially Rescues CXCR4-Mediated Retention of Neutrophils in the CHT
(A) Tg(mpx:CXCR4-WHIM) was crossed with Rac2 or D57N lines and circulating neutrophils were quantified. n = 26 each. p < 0.001, two-tailed Mann-Whitney U test.
(B) Fluorescent signal in boxed region was stacked vertically into one-dimensional line at each time point. Kymography of 4-min movies with 2-s interval is shown. Horizontal lines indicate auto-fluorescent pigments that are stationary throughout the movie. Arrows indicate neutrophils circulating in the PCV. Scale bar represents 100 μm.
See also Figure S5.
Figure Data
Acknowledgments
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Reprinted from Developmental Cell, 21(4), Deng, Q., Yoo, S.K., Cavnar, P.J., Green, J.M., and Huttenlocher, A., Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue, 735-745, Copyright (2011) with permission from Elsevier. Full text @ Dev. Cell