ZFIN Image: Waxman et al., 2011, Fig. 3

Image

Figure Caption

Fig. 3

Ectopic expression of zebrafish RARs does not sensitize embryos to RA signaling. (A) Schematic composition of RAR constructs used in experiments. (B) Uninjected Tg(12XRARE-ef1a:gfp) embryo. (C, D) Tg(12XRARE-ef1a:gfp) embryos injected with zebrafish rarab (C) or rarga (D) mRNA appear normal, and reporter expression is unaffected. (E) Tg(12XRARE-ef1a:gfp) embryo continuously treated with 0.05 μM RA. (F, G) Tg(12XRARE-ef1a:gfp) embryo injected with zebrafish rarab (F) or rarga (G) mRNA and treated with 0.05 μM RA are not more affected than uninjected embryos. All images are lateral views, with anterior up and dorsal to the right.

Acknowledgments

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Reprinted from Developmental Biology, 352(1), Waxman, J.S., and Yelon, D., Zebrafish retinoic acid receptors function as context-dependent transcriptional activators, 128-140, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.