ZFIN Image: Kawahara et al., 2011, Fig. 2

Image

Figure Caption

Fig. 2

Genotype and dystrophin expression of treated fish with seven candidate chemicals from the longer screen. (A) Genotyping of each of 40 fish treated with each of the seven potential candidate chemicals. Yellow, dystrophin-null affected fish (abnormal birefringence). Red, dystrophin-null unaffected fish (normal birefringence). Blue, heterozygous fish (normal birefringence). Light blue, WT fish (normal birefringence). In each of the seven chemically treated wells, some fish show normal birefringence despite genotyping results that show dystrophin-null fish. (B–J) Immunostaining with an anti-dystrophin antibody. (B) WT. (C) Dystrophin-null fish. (D–J) Dystrophin immunostaining of fish with restored muscle structure with each of the seven chemicals (chemicals 1–7 in Table 2). All restored fish with chemicals 1–7 showed no expression of dystrophin, similar to those of untreated dystrophin-null fish (C).

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA