ZFIN Image: Tehrani et al., 2011, Fig. 4

Image

Figure Caption

Fig. 4 Decreased Hh signaling leads to increased numbers of RA-induced pdx1-expressing cells. (A-D) Dorsal views (anterior to left) of pdx1 expression at 32 hpf in DMSO-treated wild-type (A), RA-treated wild-type (B), DMSO-treated smo^1a590 mutant (C) and RA-treated smo^1a590 mutant (D) zebrafish embryos. RA treatment (1 μM) from 9-10 hpf induced more pdx1-expressing cells in smo^1a590 mutants (D) than in wild-type embryos (B). Note the migration defect (arrows) of pdx1-expressing cells in RA-treated smo^1a590 mutants (D) as compared with RA-treated wild types (B). The number of embryos displaying similar expression patterns is indicated in each case. Asterisks indicate embryos with mixed genotypes (smo^+/+, smo^+/–, smo^-/-) from smo^1a590 carrier parents.

Acknowledgments

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