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Fig. 1 Phenotype of mutants for housekeeping genes are similar and depend on p53 network upregulation.
A–C) Excessive neural apoptosis was manifested as gray areas in the brain at 24 hpf, which was rescued by p53 inhibition D–F) At 48 hpf, there were more apoptotic cells in mutants compared to siblings and p53 inhibition led to a decrease in apoptosis. Acridine orange staining. G–I) There were fewer erythroid cells in mutants compared to siblings, which was rescued by p53 inhibition. o-dianizidine staining, 84 hpf, arrow points to erythrocytes. K–L) tp53 upregulation was higher in the brain and blood cells, 48 hpf, in situ hybridization, arrow points to erythrocytes.