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Fig. 1 A: Phylogenetic tree of Smad1 and Smad5 from zebrafish (zSmad), mouse (mSmad), and human (hSmad), calculated according to the J. Hein method (DNAstar software). B: Temporal expression profile of zebrafish bmp2b, bmp4, smad1 and, as control, ef1α (Nordness et al., 1994), determined by reverse transcriptase–polymerase chain reaction. For bmp2b and bmp4, only stages up to the 80% epiboly stage are shown.
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