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Fig. S8 Neuregulin 1 induces proliferation through ErbB-PI3K. (A) Cells from tg(Actin:EGFP) embryos injected with mRNA for Neuregulin 1 (NRG1) at the one cell-stage were transplanted into wild type embryos at the 1K cellstage. Abnormal proliferation of both labeled and unlabeled cells were frequently observed when clones were present in the skin. (B) Wild-type animals injected with mRNA for NRG1 at the 1 cell-stage and incubated in the ErbB inhibitor PD168393 never developed abnormally proliferating cells compared to injected animals incubated in DMSO (white arrowhead).
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Reprinted from Developmental Biology, 327(1), Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C., ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration, 177-190, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.