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Fig. 3 Simultaneous inhibition of EGFR and PI3K signaling affects regeneration. Transgenic animals tg(H2A:H2A-EGFP) incubated in 5 μM LY294002 and 10 μM PD168393 from the amputation moment onwards exhibit impaired localization of notochord cells and affect the timely formation of the regeneration blastema (B), compared to controls incubated in DMSO (A) (white arrowheads). The migration of highly motile cells types to the amputation plane is not affected in treated animals compared to controls (Movie S2 and S3). Scale bar 20 μm.
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Reprinted from Developmental Biology, 327(1), Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C., ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration, 177-190, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.