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Fig. 2 A Mutation in fgfr1a Causes the spd Phenotype
(A) Schematic view of predicted fgfr1a structure and site of zebrafish mutations.
(B) Nucleotide alteration in fgfr1at3R705H and fgfr1ahuW671X.
(C and D) fgfr1a expression in the developing scales and lateral-line organs in wild-type fish (C) and in remaining scales of spd fish (D) (both 10 mm standard length).
(E and F) Phenotype of transheterozygous (fgfr1at3R705H/fgfr1ahuW671X) fish (E) showing scale loss similar to spd homozygotes in different genetic backgrounds (F).
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