ZFIN Image: Zhao et al., 2009, Fig. 7

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Figure Caption

Fig. 7 Prodrug dependent ablation of specific bipolar cell types in larvae from enhancer trap lines. (A-H) Confocal images of retinal cross-sections from larvae (5 dpf) produced by mating of UAS:nfsB-mCherry transgenic fish to Tg(Gal4-VP16;UAS:eGFP)^xfz3. (A, B) Retina from a larva without the UAS:nfsB-mCherry fusion gene that was unaffected by Met treatment. (C-E) Retina from larva expressing NTR-mCherry (red) in bipolar cells. (F-H) Retina from larva expressing NTR-mCherry (red) showed loss of fluorescently labelled bipolar cells following Met treatment. (I-P) The same type of analysis as in (A-H) conducted on larvae produced by mating of UAS:nfsB-mCherry transgenic fish to Tg(Gal4-VP16;UAS:eGFP)^xfz43. (N-P) Significant degeneration and loss of labelled bipolar cells occurred in the retina of Met treated larvae. Labelling to the left indicate Met treatment (+) and no treatment (-). The crosses and different types of fluorescence are indicated at the top. Scale bar: 50 μm.

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Acknowledgments

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