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Fig. 9 Effects of Fgf or Wnt signals on neuroectodermal posteriorization can be counteracted by inhibition of Smad2/3 activities. (A, A′, E and E′) Uninjected wildtype (WT) embryos. (B–D, B′–D′, F–H and F′–H′) Embryos were injected with indicated mRNA species at the one-cell stage and examined simultaneously for expression of otx2 and hoxb1b at late gastrulation stages. (A–D and E–H) Lateral views with dorsal to the right. (A′–D′ and E′–H′) Dorsal views with the anterior to the top. (I, J) Statistical data for the percentage of embryos showing altered expression of otx2/hoxb1b.
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Reprinted from Developmental Biology, 333(2), Jia, S., Wu, D., Xing, C., and Meng, A., Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish, 273-284, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.