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Fig. 4 Tcf4 depletion in apcmcr/mcr background rescues the expression of i-fabp, but not trypsin or l-fabp. Dorsal view of 72 hpf apcmcr/mcr (A, C, E) and apcmcr/mcr;tcf4exI/exI (B, D, F) siblings after WISH for i-fabp (A, B), trypsin (C, D), and l-fabp (E, F). Histological analysis of transversal sections from the foregut of 80 hpf apcmcr/mcr (G) and apcmcr/mcr;tcf4exI/exI (H) larvae stained with hematoxylin and eosin. Apc mutant embryos fail to develop properly polarized enterocytes, whereas in the double-mutant embryos this defect is rescued.
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