ZFIN Image: Aman et al., 2008, Fig. 2

Image

Figure Caption

Fig. 2 apc^mcr Mutant Cells Display Cell-Autonomous Defects and Exert a Non-Cell-Autonomous Effect on Neighboring WT Cells

(A) Mosaic embryo generated by transplanting red fluorescently labeled apc^mcr cells into Tg(Cldnb:lynGFP) embryos.

(B and C) Higher-magnification views of the boxed areas in (A). (B) Red mutant cells are deposited and form proneuromasts in ectopic positions (arrows). (C) apc^mcr cells induce morphogenesis defects in neighboring green WT cells.

(D) Overview of an embryo generated by transplanting fluorescently labeled WT cells into apc^mcr mutant embryos.

(E and F) Higher-magnification images of two additional WT to apc^mcr transplantations.

Acknowledgments

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Reprinted from Developmental Cell, 15(5), Aman, A., and Piotrowski, T., Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression, 749-761, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell