ZFIN Image: Aman et al., 2008, Fig. S7

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Figure Caption

Fig. S7 Induction of Dominant Negative Fgfr1 Phenocopies Fgf Inhibition via SU5402 Treatment

(A and B) In wt embryos the Fgf target pea3 is expressed in the lateral line as well as many other structures. Expression of pea3 is strongly downregulated or completely abolished in embryos treated with SU5402 between 18-38hpf (C), and in 31hpf Tg(hs:dn-fgfr1) embryos at 4h post heat-shock (D). (E) Higher magnification image of the primordium of embryo shown in (D). Expression of the Fgf target dkk1 (F) is also abolished 4 hours following heatshock induction of dn-Fgfr1. (G) The Fgf pathway repressor sef is ectopically expressed in the trailing edge 4 hours following induction.

Acknowledgments

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Reprinted from Developmental Cell, 15(5), Aman, A., and Piotrowski, T., Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression, 749-761, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell