ZFIN Image: Marques et al., 2008, Fig. 4

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Figure Caption

Fig. 4 Heat shock of Tg(hsp70:ca-fgfr1) embryos causes ectopic FGF signaling and perturbs pectoral fin development. (A, B) In situ hybridization depicts pea3 expression at 32 hpf; dorsal views, anterior to the left. (A) After heat shock at 24 hpf, non-transgenic (non-tg) embryos show a wild-type restriction of pea3 expression to specific regions, including the midbrain–hindbrain boundary and the pharyngeal pouches. (B) In contrast, heat shock of transgenic (tg) embryos causes strong and ectopic expression of pea3. (C, D) Dorsal views at 72 hpf of embryos after heat shock at the 8-somite stage. (C) Non-transgenic embryos exhibit pectoral fins of normal length (bar). (D) Transgenic embryos lack at least one pectoral fin, as shown here (n = 14/50), or have two small fins (n = 31/50).

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Acknowledgments

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Reprinted from Developmental Biology, 321(2), Marques, S.R., Lee, Y., Poss, K.D., and Yelon, D., Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart, 397-406, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.